Metabolic & body composition

5-Amino-1MQ

Written by the Elevate Clinical Team

Citations independently verified against PubMed, ClinicalTrials.gov, and FDA sources on . Independent clinical review pending.

A small-molecule NNMT inhibitor studied for fat-cell metabolism and NAD+ availability.

What it is

5-Amino-1MQ inhibits nicotinamide N-methyltransferase (NNMT), an enzyme elevated in obese adipose tissue. Blocking it in animal models increases intracellular NAD+ and shrinks fat cells without changing food intake. It is a small molecule, not a peptide, and it is orally available.

What it's studied for

  • Adipocyte size and fat mass in rodent models
  • NAD+ salvage-pathway activity
  • Muscle-function research in aged animals

How it's used in practice

  • Oral administration is the usual route in research settings
  • Often bundled with NAD+ precursors in marketing; the mechanisms are related but not identical

What you should know before asking about it

  • Research use only; not FDA-approved
  • No published human trials
  • NNMT has roles beyond fat tissue that inhibition may affect

Frequently asked questions.

What is 5-Amino-1MQ?
5-Amino-1MQ inhibits nicotinamide N-methyltransferase (NNMT), an enzyme elevated in obese adipose tissue. Blocking it in animal models increases intracellular NAD+ and shrinks fat cells without changing food intake. It is a small molecule, not a peptide, and it is orally available.
What is 5-Amino-1MQ studied for?
Published and ongoing research looks at adipocyte size and fat mass in rodent models; nAD+ salvage-pathway activity; muscle-function research in aged animals. These are areas of study, not promised outcomes.
Is 5-Amino-1MQ FDA-approved?
5-Amino-1MQ has not been evaluated by the FDA. Elevate Chicago lists it for education and research reference only — it is not prescribed as medical care and is not intended for human consumption.
How is 5-Amino-1MQ typically used?
Oral administration is the usual route in research settings Often bundled with NAD+ precursors in marketing; the mechanisms are related but not identical Any specific dose, frequency or duration comes from a prescription written for you after labs — never from this page.
What are the risks and unknowns with 5-Amino-1MQ?
Research use only; not FDA-approved No published human trials NNMT has roles beyond fat tissue that inhibition may affect

Sources

  1. 1.Published literature on 5-Amino-1MQPubMed, U.S. National Library of Medicine
  2. 2.Compounding and the FDA: questions and answersU.S. Food & Drug Administration
  3. 3.Bulk drug substances nominated for use in compounding under section 503AU.S. Food & Drug Administration
  4. 4.Test directory and patient service center locatorQuest Diagnostics

About this page

Written by the Elevate Clinical Team

Citations independently verified against PubMed, ClinicalTrials.gov, and FDA sources on . Independent clinical review pending. Educational content only — not medical advice, not a diagnosis, and not an offer to sell any prescription product.

This page is educational reference material. It is not medical advice, not a diagnosis, and not an offer to sell any product. Prescription therapies are dispensed only through licensed, FDA-registered compounding pharmacies after a physician evaluation. Compounds identified as research use only are not FDA-approved, are not prescribed as medical care, and are not intended for human or animal consumption. Availability, formulations and regulatory status change over time.